| Battery | Upgrade Cooldown Tome to level 5 |
| Boss Buster | Defeat a Stage Boss in under 30 seconds |
| Cursed Doll | Die 10 times |
| Forbidden Juice | Crit 100 times |
| Key | Purchase 25 chests |
| Tactical Glasses | Defeat a Miniboss in 25 seconds |
| Turbo Socks | Upgrade Agility Tome to level 5 |
| Cactus | Kill 100 cactus enemies with Thorns damage |
| Ghost | Survive the Final Swarm for 60 seconds |
| Ice Crystal | Get 50 kills with Frostwalker |
| Skuleg | Obtain 40% Difficulty |
| Brass Knuckles | Kill 5,000 enemies with the Sword |
| Demonic Blade | Heal for 350 HP using Lifesteal |
| Demonic Blood | Increase Max HP with Blood Magic 400 times |
| Echo Shard | Upgrade XP Tome to level 8 |
| Golden Sneakers | Break 150 pots |
| Moldy Cheese | Use a Microwave to duplicate Moldy Cheese 3 times in a row |
| Idle Juice | Kill 500 enemies while standing still |
| Leeching Crystal | Upgrade Regen Tome to level 8 |
| Kevin | Obtain 3 Leeching Crystal in a run |
| Bob (Dead) | Survive the Final Swarm for 2 minutes |
| Demonic Soul | Reach level 30 as Calcium |
| Eagle Claw | Kill 10,000 enemies as Birdo |
| Gamer Goggles | Defeat a Stage Boss with less than 10% HP left |
| Gas Mask | Kill 5,000 enemies using Amog |
| Grandma's Secret Tonic | Kill 3,000 enemies with Sniper Rifle |
| Quin's Mask | Defeat a Stage Boss as Athena, landing the killing blow with Aegis |
| Shattered Knowledge | Upgrade Attraction Tome to level 8 |
| Slutty Canon | Kill 5,000 enemies with Slutty Rocket |
| Toxic Barrel | Kill 2,000 enemies using Poison damage |
| Turbo Skates | Upgrade both Cooldown Tome and Agility Tome to level 5 in a run |
| Cursed Grubbies | Get the Cursed Tome to level 10 |
| Chonkplate | Get max HP to 500 |
| Dragon Fire | Kill 4,000 enemies using fire damage |
| Holy Book | Kill a first Stage Boss without taking any damage that run |
| Lightning Orb | Kill 3,000 enemies using lightning damage |
| Speed Boi | Complete a stage with at least 2 Boss Curse activated |
| Sucky Magnet | Complete a stage with at least 2 Boss Curse activated |
| Energy Core | Complete every single Charge Shrine on the map |
| Anvil | Defeat a Final Boss 2 times |
| Soul Harvester | Survive the Final Swarm for 6 minutes |
| Joe's Dagger | Kill 10,000 enemies using the Dexecutioner |
| Bloody Cleaver | Reach level 50 as Vlad |
| Borgar | Unlocked by default |
| Wrench | Unlocked by default |
| Clover | Unlocked by default |
| Time Bracelet | Unlocked by default |
| Slippery Ring | Unlocked by default |
| Golden Glove | Unlocked by default |
| Gym Sauce | Unlocked by default |
| Oats | Unlocked by default |
| Medkit | Unlocked by default |
| Credit Card (Red) | Unlocked by default |
| Golden Shield | Unlocked by default |
| Thunder Mitts | Unlocked by default |
| Feathers | Unlocked by default |
| Electric Plug | Unlocked by default |
| Coward's Cloak | Unlocked by default |
| Unstable Transfusion | Unlocked by default |
| Beer | Unlocked by default |
| Beacon | Unlocked by default |
| Backpack | Unlocked by default |
| Phantom Shroud | Unlocked by default |
| Campfire | Unlocked by default |
| Beefy Ring | Unlocked by default |
| Credit Card (Green) | Unlocked by default |
| Spiky Shield | Unlocked by default |
| Scarf | Unlocked by default |
| Slurp Gloves | Unlocked by default |
| Mirror | Unlocked by default |
| Overpowered Lamp | Unlocked by default |
| Za Warudo | Unlocked by default |
| Big Bonk | Unlocked by default |
| Spicy Meatball | Unlocked by default |
| Ice Cube | Unlocked by default |
| Giant Fork | Unlocked by default |
| Power Gloves | Unlocked by default |
